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Dissolution and content-uniformity tests are very important and essential procedures for the controlling of medication bioavailability. Depends on the bioavailability of medication, the efficacy and safety in patient therapy are different. Currently five different manufactured acyclovir tablets (A, B, C, D and E) are available in Korea. This study performed to evaluate the bioavailability of those acyclovir tablets, and to help the clinicians for valid selection of medication in patient therapy. The study methods were consisted of the dissolution tests and content-uniformity tests of each acyclovir tablet. The dissolution tests were performed six tablets of each acyclovir in the two artificial juices for 30 minutes : (1) a gastric juice with pH 1.2, (2) a enteric juice with pH 6.8. The content-uniformity tests were performed the measurements of ten solutions (200 mcg/㎖) made by each acyclovir tablet, and compared them with the standard solution. All tests were measured by the HPLC method. The results of the dissolution tests showed that both cases ((1) & (2)) were presented on tablet A, B, E, D and C in high dissolution rate order, and also all acyclovir tablets meet for the standard of KP Ⅶ (90% above) in the content-uniformity tests. In conclusion, the good quality of medication is very important to increase the efficacy and safety of patient therapy, and is determined by the bioavailability measurements of each medication. The conducting of bioavailability tests for each medication must be performed on the regular basis.
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